Arginine Consumption by the Intestinal Parasite Giardia intestinalis Reduces Proliferation of Intestinal Epithelial Cells
نویسندگان
چکیده
منابع مشابه
Arginine Consumption by the Intestinal Parasite Giardia intestinalis Reduces Proliferation of Intestinal Epithelial Cells
In the field of infectious diseases the multifaceted amino acid arginine has reached special attention as substrate for the hosts production of the antimicrobial agent nitric oxide (NO). A variety of infectious organisms interfere with this part of the host immune response by reducing the availability of arginine. This prompted us to further investigate additional roles of arginine during patho...
متن کاملintestinalis GiardiaMaterial in the Binucleate Intestinal Parasite
www.sciencemag.org (this information is current as of March 23, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/319/5869/1530 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/319/5869/1530/DC1 can be foun...
متن کاملCharacterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells
BACKGROUND Giardia intestinalis is a non-invasive protozoan parasite that causes giardiasis in humans, the most common form of parasite-induced diarrhea. Disease mechanisms are not completely defined and very few virulence factors are known. METHODOLOGY To identify putative virulence factors and elucidate mechanistic pathways leading to disease, we have used proteomics to identify the major e...
متن کاملAttachment of Giardia lamblia to rat intestinal epithelial cells.
The human enteric protozoan, Giardia lamblia, has surface membrane lectin activity which mediates parasite adherence to erythrocytes. To determine whether an intestinal binding site exists for this lectin we have studied the interaction in vitro between axenically cultured Giardia trophozoites and isolated rat intestinal epithelial cells. Scanning electron microscopy showed that Giardia attache...
متن کاملMechanisms of adaptation in the intestinal parasite Giardia lamblia.
Giardia lamblia, a parasite of humans, is a major source of waterborne diarrhoeal disease. Giardia is also an excellent system to study basic biochemical processes because it is a single-celled eukaryote with a small genome and its entire life cycle can be replicated in vitro. Giardia trophozoites undergo fundamental changes to survive outside the intestine of their host by differentiating into...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0045325